Anionic amphiphilic dendrimers as antibacterial agents

…, AP Griset, NR Luman, MW Grinstaff

文献索引：Meyers, Steven R.; Juhn, Frank S.; Griset, Aaron P.; Luman, Nathanael R.; Grinstaff, Mark W. Journal of the American Chemical Society, 2008 , vol. 130, # 44 p. 14444 - 14445

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被引用次数: 79

摘要

An anionic amphiphilic dendrimer is reported that possesses increased cytotoxicological potency against prokaryotic cells compared to eukaryotic cells. The half-maximal effective concentration (EC50) for the dendrimer against Bacillus subtilis, a Gram-positive bacterial strain, was measured to be 4.1× 10− 5 M, while that against human umbilical vein endothelial cells (HUVEC) was more than 36× greater at a value of 1.5× 10− 3 M. EC50 ...