An enantioselective synthesis of (−)-4-hydroxy-6-methoxy-3a, 8a-dihydrofuro [2, 3-b] benzofuran: an advanced intermediate in the synthesis of (−)-aflatoxin B 1 and G …
JP Marino, KA Kieler, MW Kim
文献索引：Marino, Joseph P.; Kieler, Karen A.; Kim, Min-Woo Tetrahedron, 2011 , vol. 67, # 5 p. 837 - 841
The Aflatoxins (Fig. 1), secondary metabolites of the fungus Aspergillus, are among the most potent carcinogens known to man. The fused dihydrobisfuran ring system of these mycotoxins contains an electron rich double bond that undergoes metabolic activation to an epoxide, which can then generate covalent lesions upon intercalation into double stranded DNA. 1 Recent reports on the preparation and use of the 8, 9-epoxide of Aflatoxin B1 by ...
