5, 7-Dihydroxychromone-2-carboxylic acid and it's transition-metal (Mn and Zn) chelates as non-thiol radioprotective agents

SJ Hosseinimehr, S Emami, SM Taghdisi…

文献索引：Hosseinimehr, Seyed Jalal; Emami, Saeed; Taghdisi, Seyed Mohammad; Akhlaghpoor, Shahram European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 557 - 561

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被引用次数: 10

摘要

5, 7-Dihydroxychromone-2-carboxylic acid (DHCCA) and its related complexes with manganese and zinc were prepared and evaluated for radioprotection activity against gamma irradiation in mice. The LD50 values were found to be more than 1500 and 1000mg/kg for DHCCA and it's complexes, respectively. For studying radioprotective effects, 1.0 mmol/kg and 0.5 mmol/kg doses of compounds were administrated subcutaneously ...