European journal of medicinal chemistry

Carbonic anhydrase inhibitors. Part 61. Quantum chemical QSAR of a group of benzenedisulfonamides

BW Clare, CT Supuran

文献索引：Clare, Brian W.; Supuran, Claudiu T. European Journal of Medicinal Chemistry, 1999 , vol. 34, # 6 p. 463 - 474

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被引用次数: 74

摘要

The synthesis of a large group of benzenesulfonamides containing both a primary and secondary sulfonamide moiety is described. These compounds are powerful inhibitors of several isozymes of the enzyme carbonic anhydrase. Separate QSAR's are given for inhibition of three of these isozymes, using descriptors mainly derived from molecular orbital calculations by the semiempirical AM1 method. Activity was found to depend on ...