A novel approach to the synthesis of an enantiopure bicyclic proline analogue, hexahydrocyclopenta [b] pyrrole-6a (1H)-carboxylic acid ('2, 3-propanoproline'), has been developed. The method relied on tandem Strecker-nucleophilic cyclization reaction of 2-(2- bromoethyl) cyclopentanone. The overall synthetic scheme included six steps and resulted in 18% overall yield of both enantiomers of the title amino acid.
