A simple synthesis of trans-3, 4, 5-trimethoxycinnamamides and evaluation of their biologic activity

JC Jung, D Min, H Lim, S Moon, M Jung…

文献索引：Jung, Jae-Chul; Min, Dongguk; Lim, Heena; Moon, Sohyeon; Jung, Mankil; Oh, Seikwan Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 4615 - 4621

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摘要

Abstract A simple synthesis and biologic evaluation of trans-3, 4, 5-trimethoxycinnamamides 10a–e and 11 as novel antinarcotic agents is described. The synthetic key strategies involve condensation reaction and coupling reaction to generate trans-3, 4, 5- trimethoxycinnamamides 10a–e and 11. They were evaluated for free radical scavenging, inhibitory action for neurotoxicity in cultured neurons, and antinarcotic activity in mice. It ...