Synthesis of photo-responsive acridine-modified DNA and its application to site-selective RNA scission

…, Y Yamamoto, A Kuzuya, M Komiyama

文献索引：Tanaka, Keita; Yamamoto, Yoji; Kuzuya, Akinori; Komiyama, Makoto Nucleosides, Nucleotides and Nucleic Acids, 2008 , vol. 27, # 10-11 p. 1175 - 1185

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被引用次数: 5

摘要

Photo-responsive phosphoramidite monomers, which bear an azobenzene between acridine and the phosphoramidite unit, were synthesized, and incorporated into oligonucleotides. Upon UV irradiation, the azobenzene in the modified DNA efficiently isomerized from the trans isomer into the cis isomer. Although the Tm values of their duplexes with complementary DNA were not much changed by the isomerization, site- ...