Development of polyamine transport ligands with improved metabolic stability and selectivity against specific human cancers

…, J Kamel, N Kaur, AC Shicora, IS Ayene…

文献索引：Muth, Aaron; Kamel, Joseph; Kaur, Navneet; Shicora, Allyson C.; Ayene, Iraimoudi S.; Gilmour, Susan K.; Phanstiel, Otto Journal of Medicinal Chemistry, 2013 , vol. 56, # 14 p. 5819 - 5828

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被引用次数: 6

摘要

Polyamine homeostasis is critical for life and is accomplished via a balance of polyamine biosynthesis, degradation, and transport. Rapidly dividing cancer cells have been shown to have high polyamine transport activity compared to normal cells, likely due to their high requirement for polyamine metabolites. The polyamine transport system (PTS) is a therapeutically relevant target, as it can provide selective drug delivery to cancer cells. ...