Controlling substitution patterns on the 1, 2, 4??triazolo [1, 5?螃?]??pyrimidine ring. Selective removal of chlorine at the 7??position

…, WA Kleschick, J Bordner

文献索引：Monte, William T.; Kleschick, William A.; Bordner, Jon Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 1 p. 183 - 188

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被引用次数: 5

摘要

Abstract A highly effective method for the selective removal of chlorine from the 7-position of the 1, 2, 4-triazolo [1, 5-α] pyrimidine ring in the presence of chlorine at the 5-or 6-positions is reported. The method involves treatment of the appropriate substrate with zinc-copper couple in the presence of acetic acid in methanol-tetrahydrofuran. The method enables the construction of a variety of substitution patterns in key intermediates for the 1, 2, 4-triazolo [ ...