Binding of a homologous series of anthraquinones to DNA

RE McKnight, J Zhang, DW Dixon

文献索引：McKnight, Ruel E.; Zhang, Jianguo; Dixon, Dabney W. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 401 - 404

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被引用次数: 33

摘要

The DNA binding characteristics of a series of homologous 2, 6-disubstituted anthraquinone threading intercalators bearing one to four ethylene glycol units in their side chains have been studied. Binding constants were measured via surface plasmon resonance (SPR). These compounds bind to an AT-rich hairpin with slightly higher affinity than to a GC-rich hairpin. The binding constants decrease as the length of the side chain increases.