Synthesis and evaluation of pyrazolo [3, 4-b] pyridine CDK1 inhibitors as anti-tumor agents

…, AR Fuentes-Pesquera, LM Greenberger

文献索引：Lin, Ronghui; Connolly, Peter J.; Lu, Yanhua; Chiu, George; Li, Shengjian; Yu, Yang; Huang, Shenlin; Li, Xun; Emanuel, Stuart L.; Middleton, Steven A.; Gruninger, Robert H.; Adams, Mary; Fuentes-Pesquera, Angel R.; Greenberger, Lee M. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 15 p. 4297 - 4302

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被引用次数: 55

摘要

A series of 3, 5-disubstituted pyrazolo [3, 4-b] pyridine cyclin-dependent kinase (CDK) inhibitors was synthesized. These compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in cultured human tumor cells. Selected compounds were evaluated in an in vivo tumor xenograft model. The synthesis and biological evaluation of these pyrazolo [3, 4-b] pyridines and related compounds are ...