Benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogues of the tallimustine: synthesis and antitumour activity

…, MG Pavani, M del Carmen Nunez, JP Bingham…

文献索引：Baraldi, Pier Giovanni; Romagnoli, Romeo; Giovanna Pavani, Maria; Carmen Nunez, Maria; Bingham, John P.; Hartley, John A. Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1611 - 1618

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被引用次数: 23

摘要

A series of benzoyl and cinnamoyl nitrogen mustards tethered to different benzoheterocycles and to oligopyrroles structurally related to netropsin consisting of two pyrrole-amide units and terminating with an amidine moiety have been synthesised and a structure–activity relationship determined. Derivatives 3–10 have been evaluated for their sequence selective alkylating properties and cytotoxicity against human K562 leukaemia ...