Optimized catalytic enantioselective aryl transfer process gives access to mGlu2 receptor potentiators

…, JM Schkeryantz, BW Shaw, MA Staszak

文献索引：Magnus, Nicholas A.; Anzeveno, Peter B.; Coffey, D. Scott; Hay, David A.; Laurila, Michael E.; Schkeryantz, Jeffrey M.; Shaw, Bruce W.; Staszak, Michael A. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 560 - 567

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被引用次数: 30

摘要

An asymmetric enantioselective aryl transfer reaction was developed to give access to the diarylmethanol 7 and ultimately acetate 2 which is useful for the preparation of mGlu2 receptor potentiators (Scheme 3). The aryl transfer chemistry involved the preparation of a proposed arylalkylzinc species 14 from boroxine 16 and diethylzinc (DEZ), and reacting this mixture with aldehyde 5 in the presence of chiral ligand 15. During the course of ...