Potential antitumor agents. 47. 3'-Methylamino analogs of amsacrine with in vivo solid tumor activity

…, BC Baguley, GJ Finlay, GW Rewcastle…

文献索引：Atwell, Graham, J.; Baguley, Bruce C.; Finlay, Graeme J.; Rewcastle, Gordon W.; Denny, William A. Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1769 - 1776

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被引用次数: 17

摘要

Replacement of the 3'-methoxy group of the clinical antileukemic agent amsacrine (1) with a 3'-methylamino group provides a compound (3) with a broader spectrum of action, including in vivo activity against experimental solid tumors. The synthesis, physicochemical properties, and biological activity of a series of acridine-substituted analogues of 3 are described. The compounds show higher levels of DNA binding, water solubility, and in vivo solid tumor ...