Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential

Y Kanekar, K Basha, S Duche, R Gupte…

文献索引：Kanekar, Yogesh; Basha, Khalander; Duche, Sharad; Gupte, Rajan; Kapat, Arnab European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 454 - 463

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被引用次数: 4

摘要

Abstract Regioselective synthesis of 9, 10-Dihydro-2, 5-Dimethoxyphenanthrene-1, 7-diol (1) and 9, 10-Dihydro-2, 7-Dimethoxyphenanthrene-1, 5-diol (2) was achieved using regioselective methylation, Wittig reaction, intramolecular cyclization and hydrogenation as key steps. The synthesis was successfully completed in total of 15 steps with 3.3% overall yield in case of 1 and in total of 13 steps with 9.0% overall yield in case of 2. All ...