Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole

AS Lages, KCM Silva, ALP Miranda, CAM Fraga…

文献索引：Lages, Adriana S.; Silva, Kelli C. M.; Miranda, Ana L. P.; Fraga, Carlos A. M.; Barreiro, Eliezer J. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 2 p. 183 - 188

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被引用次数: 28

摘要

Four new aryl-sulfonamide derivatives (3a, 4a, 5a∼ b), having methylenedioxy group attached to phenyl ring, were prepared from natural safrole and evaluated as anti- inflammatory agents. The N-methylsulfonamide 3a and corresponding retrosulfonamide derivative 5a were more active than standards indomethacin and nimesulide, at the same molar concentration, in carrageenan-induced pleurisy assay.