Organic letters

Highly regio-and enantioselective organocatalytic conjugate addition of alkyl methyl ketones to a β-silylmethylene malonate

R Chowdhury, SK Ghosh

文献索引：Chowdhury, Raghunath; Ghosh, Sunil K. Organic Letters, 2009 , vol. 11, # 15 p. 3270 - 3273

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被引用次数: 27

摘要

(S)-N-(2-Pyrrolidinylmethyl) pyrrolidine/trifluoroacetic acid (3: 1) combination catalyzed the direct addition of alkyl methyl ketones to β-dimethyl (phenyl) silylmethylene malonate at the methyl terminal with high yield and excellent regio-and enantioselectivity. The silyl group played crucial roles in regioselection and substrate reactivity.