Fluorinated phenylcyclopropylamines. Part 4: Effects of aryl substituents and stereochemistry on the inhibition of monoamine oxidases by 1-aryl-2-fluoro- …
S Ye, S Yoshida, R Fröhlich, G Haufe, KL Kirk
文献索引：Ye, Song; Yoshida, Shinichi; Froehlich, Roland; Haufe, Guenter; Kirk, Kenneth L. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2489 - 2499
A series of para-ring-substituted (E)-and (Z)-1-aryl-2-fluorocyclopropylamines were examined as inhibitors of recombinant human liver monoamine oxidase A (MAO A) and B (MAO B). Unlike the parent 1-phenylcyclopropylamine, which is a selective inhibitor of MAO B, both (E)-and (Z)-diastereomers of derivatives having fluorine at the 2-position of the cyclopropane ring were potent and selective irreversible inhibitors of MAO A. Both ...
