Tetrahedron: Asymmetry

New synthetic approach to mevalonate and mevaldate fluoroanalogues

…, II Gerus, VP Kukhar, OV Manoilenko

文献索引：Kondratov, Ivan S.; Gerus, Igor I.; Kukhar, Valery P.; Manoilenko, Olga V. Tetrahedron Asymmetry, 2007 , vol. 18, # 16 p. 1918 - 1925

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被引用次数: 11

摘要

6, 6, 6-Tri-and 6, 6-difluoromevalonate were synthesized by new method starting from the corresponding β-alkoxyvinyl polyfluoromethyl ketones. Enantiomers of fluoromevalonates were obtained by column chromatography separation of diastereomeric (S)-(−)-1- phenylethylamides of fluoromevalonates with the following hydrolysis. Racemic 6, 6, 6-tri- and 6, 6-difluoromevaldates were also prepared.