Synthesis of the 3H-azepines utilizing the thermolysis of substituted aryl azides

Y Ohba, S Kubo, M Nakai, A Nagai…

文献索引：Ohba; Kubo; Nakai; et al. Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 7 p. 2317 - 2320

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被引用次数: 7

摘要

Thermolysis of several p-substituted aryl azides (p-RC 6 H 4 N 3; R= COCH 3, CO 2 CH 3, COPh) in methanol gave 5-substituted 2-methoxy-3H-azepines in moderate yields. Thermolysis of m-substituted aryl azides (m-RC 6 H 4 N 3; R= COCH 3, CO 2 CH 3, COPh, NO 2) gave 4-substituted 2-methoxy-3H-azepines and 6-substituted 2-methoxy-3H-azepines in good yields. In contrast, thermolysis of p-azidoacetophenone in piperidine gave 5- ...