Neuroleptic agents derived from perathiepin: 6, 7-Dichloro derivative of 10-(4-methylpiperazino)-10, 11-dihydrodibenzo [b, f] thiepin and related compounds

…, J Pomykáček, J Metyšová, M Protiva

文献索引：Jilek; Pomykacek; Metysova; Protiva Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 7 p. 1607 - 1613

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被引用次数: 2

摘要

Abstract The reaction of 2, 3-dichlorothiophenol with 2-iodobenzoic acid gave 2-(2, 3- dichlorophenylthio) benzoic acid (V) which was transformed in four steps to the homological acid IX. Cyclization resulted in 6, 7-dichlorodibenzo [b, f] thiepin-10 (11H)-one (X) which was converted via the alcohol XI to the trichloro compound XII. Substitution reactions of XII with 1- methylpiperazine and 1-(2-hydroxyethyl) piperazine afforded the title compound I and its ...