Microwave-assisted “libraries from libraries” approach toward the synthesis of allyl-and C-cyclopropylalkylamides

…, YA Shafer, CRJ Stephenson, C Kendall…

文献索引：Wipf, Peter; Kendall, Christopher; Stephenson, Corey R. J. Journal of the American Chemical Society, 2003 , vol. 125, # 3 p. 761 - 768

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被引用次数: 26

摘要

Cascade reactions of internal and terminal alkynes, zirconocene hydrochloride, dimethylzinc, and phosphinoyl imines (prepared in one step from aldehydes and diphenylphosphinoyl amide) lead to allylic phosphinoyl amides after aqueous workup. Microwave acceleration allows the completion of this one-pot reaction sequence in 10 min. These allylic amides can be converted into a variety of derivatives, including carbamates ...