Monobactams. The conversion of 6-APA to (S)-3-amino-2-oxoazetidine-1-sulfonic acid and its 3 (RS)-methoxy derivative

CM Cimarusti, HE Applegate, HW Chang…

文献索引：Cimarusti, C. M.; Applegate, H. E.; Chang, H. W.; Floyd, D. M.; Koster, W. H.; et al. Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 179 - 180

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被引用次数: 31

摘要

Monobactams. The Conversion of 6-APA to (S)-3-Amino-2-oxoazetidine-l-sulfonic Acid and Its 3(RS)-Methoxy Derivative Summary: A facile conversion of 6-APA to (S1-3-amino- monobactamic acid (3-AMA) and its 3(RS)-methoxy de- rivative, key intermediates for the synthesis of 3-(acyl- amino)-2-oxoazetidine-l-sulfonic acids (monobactams), is described. ... Sir: The isolation of various 3-(acylamino)-2-oxo- azetidine-1-sulfonic acids (1) from certain bacteria was ...