Tetrahedron

Formal total synthesis of the PKC inhibitor, balanol: preparation of the fully protected benzophenone fragment

B Laursen, MP Denieul, T Skrydstrup

文献索引：Laursen, Bolette; Denieul, Marie-Pierre; Skrydstrup, Troels Tetrahedron, 2002 , vol. 58, # 11 p. 2231 - 2238

全文：HTML全文

被引用次数: 43

摘要

The synthesis of a perbenzylated derivative of balanol's highly functionalized benzophenone fragment is reported employing a regioselective Heck reaction as the key step for the connection of the two aromatic rings. The intermediate 7-membered lactone obtained, is subsequently opened and then subjected to an oxidative degradation, resulting in a short synthesis of the benzophenone unit. As the benzophenone has previously been ...