Total synthesis and dual PPARα/γ agonist effects of amorphastilbol and its synthetic derivatives

…, W Lee, KH Jeong, JH Song, SH Park, P Choi…

文献索引：Kim, Taejung; Lee, Woojung; Jeong, Kyu Hyuk; Song, Jung Ho; Park, Soon-Hye; Choi, Pilju; Kim, Su-Nam; Lee, Seokjoon; Ham, Jungyeob Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4122 - 4126

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被引用次数: 12

摘要

Amorphastilbol (APH-1), isolated from a Robinia pseudoacacia var. umbraculifer seed extract, is a biologically interesting natural trans-stilbene compound with dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist activity. After total synthesis of APH-1 and its derivatives by Pd-catalyzed Suzuki–Miyaura cross-coupling of a common (E)-styryl bromide intermediate and various aromatic trifluoroborate compounds, we biologically ...