Abstract Novel acyclic nucleosides 3a, b, c where N-1 of acyclovir is replaced by oxygen atom were prepared. Thus, 1-[(2-acetoxyethoxy) methyl]-5-amino-4- ethoxycarbonylimidazole (9) was treated with ethoxycarbonyl isothiocyanate or benzoyl isothiocyanate to give 11e, f. Methylation of the latter with methyl iodide afforded S- methylisothiourea derivative 12f which was treated with alkali and subsequently the ...
![5-(N'-Ethoxycarbonyl.S-methylisothiocarbamoyl)amino-1-[(2-hydroxyethoxy)methyl]-4-ethoxycarbonylimidazole结构式](https://image.chemsrc.com/caspic/084/121129-61-1.png)
![1-[(2-Acetoxyethoxy)methyl]-5-(N'-ethoxycarbonylthiocarbamoyl)amino-4-ethoxycarbonylimidazole结构式](https://image.chemsrc.com/caspic/264/121107-21-9.png)