Steroids

Design, synthesis, cytocidal activity and estrogen receptor α affinity of doxorubicin conjugates at 16α-position of estrogen for site-specific treatment of estrogen …

P Saha, S Fortin, V Leblanc, S Parent, É Asselin…

文献索引：Saha, Pijus; Fortin, Sebastien; Leblanc, Valerie; Parent, Sophie; Asselin, Eric; Berube, Gervais Steroids, 2012 , vol. 77, # 11 p. 1113 - 1122

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被引用次数: 9

摘要

Doxorubicin (DOX) is an important medicine for the treatment of breast cancer, which is the most frequently diagnosed and the most lethal cancer in women worldwide. However, the clinical use of DOX is impeded by serious toxic effects such as cardiomyopathy and congestive heart failure. Covalently linking DOX to estrogen to selectively deliver the drug to estrogen receptor-positive (ER+) cancer tissues is one of the strategies under ...