Solid-phase exchange radioiodination of aryl iodides. Facilitation by ammonium sulfate

TJ Mangner, JL Wu, DM Wieland

文献索引：Mangner, Thomas J.; Wu, Jiann-long; Wieland, Donald M. Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1484 - 1488

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被引用次数: 127

摘要

A mild and simple technique for the synthesis of aryl radioiodides of high specific activity involving a solid-phase exchange between no-carrier-added radioiodide and unactivated aryl iodides is described. Mildly acidic, oxidizing conditions, provided by the in situ thermal decomposition of ammonium sulfate, appear to be necessary for the success of the exchange. Typical isolated radiochemical yields of> 70% have been obtained for a variety ...