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Synthesis and biological evaluation of a novel anti-malarial lead

…, S Choi, P Carvalho, H Liu, S Khan, MA Avery

文献索引:Hammond, Nicholas L.; Choi, Seoung-Ryoung; Carvalho, Paulo; Liu, Hua; Khan, Shabana; Avery, Mitchell A. Medicinal Chemistry Research, 2011 , vol. 20, # 4 p. 401 - 407

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被引用次数: 1

摘要

Abstract Malaria is re-emerging in many tropical areas of the world and is often fatal due to drug resistance, leading to about a million deaths each year. Multiple drug resistance has required new efforts in drug discovery and development. Thus, the search for new drugs operating by novel mechanisms of action is receiving increased attention. Herein we report the synthesis and biological evaluation of a novel anti-malarial with micromolar activity ...