Chemical communications

cis-Cyclopentyl PNA (cp PNA) as constrained chiral PNA analogues: stereochemical dependence of DNA/RNA hybridization

T Govindaraju, VA Kumar, KN Ganesh

文献索引：Govindaraju; Kumar, Vaijayanti A; Ganesh, Krishna N Chemical communications (Cambridge, England), 2004 ,  # 7  p. 860 - 861

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被引用次数: 22

摘要

Peptide nucleic acids (PNA, I) are oligonucleotide mimics in which the sugar-phosphate backbone is replaced by a pseudopeptide scaffold composed of N-(2-aminoethyl)glycine units. 1 The nucleobases A/T/C/G are attached to the scaffold via carbonylmethyl spacers. PNA binds to complementary DNA/RNA with high sequence specificity and selectivity to form duplexes via Watson–Crick base pairs and triplexes through Watson–Crick and Hoogsteen hydrogen bonding. 1 Because ...