Synthesis of N 4-Substituted Derivatives of 1-[2-(Phosphonomethoxy) ethyl] cytosine and Its Diisopropyl Ester as a Model Reaction for the Synthesis of N 4-Substituted …
…, A Holı, M Masojídková
文献索引：Chalupova, Sarka; Holy, Antonin; Masojidkova, Milena Collection of Czechoslovak Chemical Communications, 2005 , vol. 70, # 12 p. 2066 - 2074
Abstract We have studied the reaction of 1-[2-(phosphonomethoxy) ethyl] cytosine (1) and its diisopropyl ester (2) with triethylammonium hydrogensulfite in 60% aqueous methanol. In the presence of some primary or secondary amine salts, at 25-70 C, this reaction affords transaminated derivatives 4a-4e and 5a, 5b as main products accompanied by uracil compounds. However, with certain amines the reaction failed.
