The Journal of Organic Chemistry

Conceptual basis of the selective activation of bis (dialkylamino) methoxyphosphines by weak acids and its application toward the preparation of deoxynucleoside …

MF Moore, SL Beaucage

文献索引：Moore, Michael F.; Beaucage, Serge L. Journal of Organic Chemistry, 1985 , vol. 50, # 12 p. 2019 - 2025

被引用次数: 30

摘要

The concept behind the selective activation of bis (dialky1amino) methoxyphosphines is experimentally examined and subsequently used in the preparation of deoxynucleoside phosphoramidites in situ. These intermediates are most efficiently prepared from the reaction of suitably protected deoxynucleosides with dipyrrolidinomethoxyphosphine in the presence of 4, 5-dichloroimidazole using 1-methyl-2-pyrrolidinone as solvent. The purity ...