Metabolism of Deuterated Isomeric 6, 7??Dihydroxydodecanoic Acids in Saccharomyces cerevisiae–Diastereo??and Enantioselective Formation and Characterization of …
LA Garbe, R Tressl
文献索引：Garbe, Leif-A.; Tressl, Roland Helvetica Chimica Acta, 2003 , vol. 86, # 7 p. 2349 - 2363
Abstract The chemical synthesis of deuterated isomeric 6, 7-dihydroxydodecanoic acid methyl esters 1 and the subsequent metabolism of esters 1 and the corresponding acids 1a in liquid cultures of the yeast Saccharomyces cerevisiae was investigated. Incubation experiments with (6R, 7R)-or (6S, 7S)-6, 7-dihydroxy (6, 7-2 H 2) dodecanoic acid methyl ester ((6R, 7R)-or (6S, 7S)-(6, 7-2 H 2)-1, resp.) and (±)-threo-or (±)-erythro-6, 7-dihydroxy ...
