11 C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain

…, BT Christian, S Chattopadhyay, TK Narayanan

文献索引：Mukherjee, Jogeshwar; Shi, Bingzhi; Christian, Bradley T.; Chattopadhyay, Sankha; Narayanan, Tanjore K. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 1 p. 95 - 102

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被引用次数: 29

摘要

Fallypride [benzamide, 5-(3-fluoropropyl)-2, 3-dimethoxy-N-[(2S)-1-(2-propenyl)-2- pyrrolidinyl] methyl]-, CAS RN 166173-78-0] is a selective dopamine D2/D3 receptor antagonist. Carbon-11 labeled fallypride may serve as a radiotracer for use in biomedical imaging technique positron emission tomography (PET). The precursor, 5-(3-fluoropropyl)-2- hydroxy-3-methoxy-N-[(2S)-1-(2-propenyl)-2-pyrrolidinyl] methyl] benzamide was ...