Bioorganic & medicinal chemistry

Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates

C Dong, Y Wang, YZ Zhu

文献索引：Dong, Cunnan; Wang, Yang; Zhu, Yi Zhun Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 9 p. 3499 - 3507

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被引用次数: 33

摘要

The synthesis and bioactivities of Danshensu derivatives (R)-methyl 2-acetoxy-3-(3, 4- diacetoxyphenyl) propanoate (1a),(R)-methyl 2-acetoxy-3-(3, 4-methylenedioxyphenyl) propanoate (1b) and their racemates 7 and 10 were reported in this paper. These derivatives were designed to improve their chemical stability and liposolubility by protecting Danshensu's phenolic hydroxyl groups with acetyl or methylene which could be readily ...