Diastereoselectivity and site dependency in the photochemistry of ketoprofen in the bovine serum albumin matrix

S Monti, I Manet, F Manoli, R Morrone…

文献索引：Monti, Sandra; Manet, Ilse; Manoli, Francesco; Morrone, Raffaele; Nicolosi, Giovanni; Sortino, Salvatore Photochemistry and Photobiology, 2006 , vol. 82, # 1 p. 13 - 19

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被引用次数: 25

摘要

ABSTRACT The photodegradation of the S (+)-and R (–)-ketoprofen (KP) enantiomers in the bovine serum albumin matrix was studied by steady-state photolysis with the use of λirr> 320 nm and transient absorption spectroscopy with λ exc= 355 nm, at 1/1 and 2/1 KP/BSA molar ratios. R (–)-KP was found to be more labile than S (+). Triplet ketoprofen species were evidenced with lifetimes of 400 ns for S (+) and 600 ns for R (–)-KP. Further longer-lived ...