Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4, 5-diphenyl-2-oxazolyl) ethyl] phenoxy] acetic acid substituted. alpha. to the oxazole ring
The 4, 5-diphenyloxazole derivatives 2-4 were previously identified as nonprostanoid prostacyclin (PGI2) mimetics. A series of derivatives of 2-4 bearing substitutents at the carbon atom cy to the oxazole ring were synthesized and evaluated as inhibitors of ADP- induced aggregation of human platelets in vitro. In the unsaturated series, the a-carbethoxy derivative loa, evaluated as an equal mixture of geometrical isomers, inhibited platelet ...
