Synthesis and antiproliferative activity of indolizinophthalazine-5, 12-dione derivatives, DNA topoisomerase IB inhibitors

DQ Shen, ZP Wu, XW Wu, ZY An, XZ Bu, LQ Gu…

文献索引：Shen, De-Qing; Wu, Zu-Ping; Wu, Xi-Wei; An, Zeng-Yun; Bu, Xiang-Zhang; Gu, Lian-Quan; Huang, Zhi-Shu; An, Lin-Kun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3938 - 3942

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被引用次数: 12

摘要

A series of novel indolizinophthalazine-5, 12-dione derivatives were designed and synthesized by the reaction of 6, 7-dichlorophthalazine-5, 8-dione with active methylene reagents (AMR) and pyridine derivatives. Some of synthesized compounds exhibited significant in vitro antiproliferative activity at micromolar level toward four human tumor cell lines, including lung adenocarcinoma cell, large-cell lung carcinoma cell, breast ...