Bulletin of the Chemical Society of Japan

Synthesis of 4-(2-Thienyl) pyrimidine Derivatives. Studies on Heterocyclic Chemistry. VI

T Nishiwaki

文献索引：Nishiwaki,T. Bulletin of the Chemical Society of Japan, 1970 , vol. 43, p. 937 - 939

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被引用次数: 3

摘要

Friedel-Crafts reaction of II with acetic acid in the presence of polyphosphoric acid produced 2-isoamyl-5-acetylthiophene (V), from which a B-diketone VIII was derived. The structure of V was verified by NMR spectrum, 5) which showed in carbon tetrachloride two fl-protons of thiophene ring at 1 3.22 (dd, J= 4.0 Hz and J= 1.0 Hz,* 1 C3—H) and T 2.52 (d, J= 4.0 Hz, C4—H). An additional support is provided by reduction of V to 2-isoamyl-5-ethylthiophene ...