Design of Chimeric Histone Deacetylase-and Tyrosine Kinase-Inhibitors: A Series of Imatinib Hybrides as Potent Inhibitors of Wild-Type and Mutant BCR-ABL, PDGF- …

S Mahboobi, S Dove, A Sellmer, M Winkler…

文献索引：Nagao, Yoshimitsu; Inoue, Keiko; Yamaki, Masae; Takagi, Shuzo; Fujita, Eiichi Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 2 p. 495 - 508

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被引用次数: 59

摘要

... Present address: Boehringer Ingelheim Pharma, Germany ... This might explain the complex transcriptional signatures with up- and down-regulated genes seen in HDI treated cancer cells.(21, 22) HDIs belonging to four different chemical classes are currently in phase I ... Chemistry. ...