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European journal of medicinal chemistry

Synthesis of novel sulfanilamide-derived 1, 2, 3-triazoles and their evaluation for antibacterial and antifungal activities

XL Wang, K Wan, CH Zhou

文献索引:Wang, Xian-Long; Wan, Kun; Zhou, Cheng-He European Journal of Medicinal Chemistry, 2010 , vol. 45, # 10 p. 4631 - 4639

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被引用次数: 180

摘要

A series of novel sulfanilamide-derived 1, 2, 3-triazole compounds were synthesized in excellent yields via 1, 3-dipolar cycloaddition and confirmed by MS, IR and NMR spectra as well as elemental analyses. All the compounds were screened in vitro for their antibacterial and antifungal activities. Preliminary results indicated that some target compounds exhibited promising antibacterial potency. Especially, 4-amino-N-((1-dodecyl-1H-1, 2, 3-triazol-4-yl) ...