Total Synthesis of Laulimalide: Synthesis of the Northern and Southern Fragments

…, WM Seganish, CK Chung, D Amans

文献索引：Trost, Barry M.; Seganish, W. Michael; Chung, Cheol K.; Amans, Dominique Chemistry - A European Journal, 2012 , vol. 18, # 10 p. 2948 - 2960

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被引用次数: 26

摘要

Abstract The first stage in the development of a synthetic route for the total synthesis of laulimalide (1) is described. Our retrosynthetic analysis envisioned a novel macrocyclization route to the natural product by using a Ru-catalyzed alkene–alkyne coupling. This would be preceded by an esterification of the C19 hydroxyl group, joining together two equally sized synthons, the northern fragment 7 and the southern fragment 8. Our first generation ...