Syntheses of 5-deoxy-, 5, 4'-dideoxy-, 5-deoxy-5-epichloro-, and 5, 4'-dideoxy-5, 4'-diepichlorokanamycin A.

T Miyake, T Tsuchiya, T Nishi, S Umezawa

文献索引：Miyake, Toshiaki; Tsuchiya, Tsutomu; Nishi, Toshiyuki; Umezawa, Sumio Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 4 p. 1149 - 1154

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被引用次数: 2

摘要

5, 4′-Dideoxy-5, 4′-diepichlorokanamycin A has been synthesized from 1, 3, 6′, 3 ″- tetrakis (N-benzyloxycarbonyl)-4 ″, 6 ″-O-cyclohexylidenekanamycin A by treatment with sulfuryl chloride, followed by deblocking. Similar treatment of 2′, 3′, 4′, 2 ″-tetra-O- acetyl-1, 3, 6′, 3 ″-tetrakis (N-benzyloxycarbonyl)-4 ″, 6 ″-O-cyclohexylidenekanamycin A gave 5-deoxy-5-epichlorokanamycin A. 5, 4′-Dideoxykanamycin A and 5- ...