Annelated pyrrolo-pyrimidines from amino-cyanopyrroles and BMMAs as leads for new DNA-interactive ring systems

…, M Bruno, P Diana, P Barraja, A Montalbano…

文献索引：Lauria, Antonino; Bruno, Marcella; Diana, Patrizia; Barraja, Paola; Montalbano, Alessandra; Cirrincione, Girolamo; Dattolo, Gaetano; Almerico, Anna Maria Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1545 - 1553

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被引用次数: 27

摘要

The efficient one-pot synthesis of several new tricyclic systems of type 1 and 2, obtained from the reaction of substituted 2-amino-3-cyanopyrroles and 3-amino-4-cyanopyrroles with BMMAs, is reported. The duration and yields of the reaction strongly depend on the reactivity of the starting pyrrole and on the size of the ring to be formed. Mechanist features of the reaction were investigated and proposed by studying also the reactivity of a 3- ...