A series of novel indoline derivatives with an ionizable moiety were synthesized to find a bioavailable acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with antiperoxidative activity.[7-(2, 2-Dimethylpropanamido)-4, 6-dimethyl-1-octylindolin-5-yl] acetic acid hemisulfate (2, pactimibe sulfate) with low lipophilicity and high water solubility showed good oral absorption and inhibitory activity against foam cell formation in THP-1 cells ...
