Characterization of a 5'-aldehyde terminus resulting from the oxidative attack at C5'of a 2-deoxyribose on DNA

…, G Pratviel, J Bernadou, B Meunier

文献索引：Angeloff; Dubey; Pratviel; Bernadou; Meunier Chemical Research in Toxicology, 2001 , vol. 14, # 10 p. 1413 - 1420

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被引用次数: 32

摘要

The 5'-aldehyde terminus is a DNA oxidative damage resulting from attack at C5'of 2- deoxyriboses by some potent natural or chemical DNA cleavers. To offer a fast and specific method for characterization of this type of damage, we used on-line electrospray ionization mass spectrometry (ESI-MS) detection during liquid chromatography analyses. The intrinsic reactivity of 5'-aldehyde terminus with nucleophiles (formation of hydrate with water, of a ...