Substituted 1, 8-naphthyridin-2 (1 H)-ones are superior to thymine in the recognition of adenine in duplex as well as triplex structures

…, C Christensen, G Haaima, PE Nielsen

文献索引：Eldrup, Anne B.; Christensen, Caspar; Haaima, Gerald; Nielsen, Peter E. Journal of the American Chemical Society, 2002 , vol. 124, # 13 p. 3254 - 3262

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被引用次数: 43

摘要

The synthesis and evaluation of a series of novel nucleobases based on substituted 1, 8- naphthyridin-2 (1 H)-ones are reported. The nucleobases were designed to meet the requirements for incorporation into peptide nucleic acids (PNAs) and were evaluated as part of PNA duplex and triplex nucleic acid recognition systems. Of the various nucleobases tested, only the 7-chloro-1, 8-naphthyridin-2 (1 H)-one (7-Cl-bT) nucleobase led to ...