Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

…, R Coli, N Jhawar, E Bora, S Jacques-O'Hagan…

文献索引：Tecle, Haile; Shao, Jianxing; Li, Yanhong; Kothe, Michael; Kazmirski, Steven; Penzotti, Julie; Ding, Yuan-Hua; Ohren, Jeffrey; Moshinsky, Deb; Coli, Rocco; Jhawar, Nidhi; Bora, Emilia; Jacques-O'Hagan, Suzanne; Wu, Joe Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 1 p. 226 - 229

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被引用次数: 21

摘要

An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK.