前往化源商城

Synthesis and anticancer activities of 4-(4-substituted piperazin)-5, 6, 7-trialkoxy quinazoline derivatives

…, YJ Huang, HM Xiang, PY Wang, DY Hu, W Xue…

文献索引:Zhang, Ying; Huang, Yin-Jiu; Xiang, Hong-Mei; Wang, Pei-Yi; Hu, De-Yu; Xue, Wei; Song, Bao-An; Yang, Song European Journal of Medicinal Chemistry, 2014 , vol. 78, p. 23 - 34

全文:HTML全文

被引用次数: 13

摘要

Abstract A series of 4-(4-substituted piperazin)-5, 6, 7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities. The ...