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3-Amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor

DA Scott, LA Dakin, DJ Del Valle, RB Diebold…

文献索引:Scott, David A.; Dakin, Les A.; Del Valle, David J.; Bruce Diebold; Drew, Lisa; Gero, Thomas W.; Ogoe, Claude A.; Omer, Charles A.; Repik, Galina; Thakur, Kumar; Ye, Qing; Zheng, Xiaolan Bioorganic and Medicinal Chemistry Letters, 2011 ,  vol. 21,  # 5  p. 1382 - 1384

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被引用次数: 16

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... 3-Amido-4-anilinocinnolines have been identified as potent and highly selective inhibitors of CSF-1R. The synthesis and SAR of these compounds is reported, along with some physical property, pharmacokinetic and kinase selectivity data. ... To establish whether cinnolines ...